Omega-3 (EPA/DHA)
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the two key long-chain omega-3 fatty acids with the strongest clinical evidence. EPA is primarily associated with cardiovascular and anti-inflammatory effects; DHA is the dominant structural fat in the brain and retina. Both are found in fatty fish and algae-based supplements. A typical supplementation dose is 1–2g combined EPA+DHA daily. Most Western diets are significantly deficient in these relative to omega-6 fatty acids.